Improving Your Life Using Only Kratom
Kratom alkaloids are effective painkillers, and orally active use. These effects are comparable with codeine in strength, but in quality. According to the database Micromedex Poisindex, 50 mg of pure mitragynine cause desire to move, dizziness, body swaying or falling, if the person is standing straight, with eyes closed (the result of the loss of the feeling of unity of the situation), twitching of facial muscles, limbs and tongue. Find more by click here.
Opiate effects, probably carried out via the delta and mu receptors opioydnye. At low Kratom dosage, mitragynine shows the relationship with the alpha-adrenergic receptors, in the manner of yohimbine, as well as a connection to the delta receptors opioydnymi. With increasing doses, the relationship with the delta-receptors is enhanced; followed crossover mu receptors. Mu crossover is enhanced by the presence of opiates.
It was found that 7-hidroksimitraginin, most likely – the main active ingredient. By its weight he is 30-46 times stronger than mitragynine, and 17 times – morphine. If the structure of the main alkaloids of Kratom resemble psychedelic, their effect is radically different. The effect is similar to opioids, and includes analgesia and cough suppression. Unlike opiates, mitragynine cough suppression exercises without causing vomiting and difficulty breathing. However, Kratom suppresses opiate cancellation, and its effects are canceled opiate antagonists such as naloxone, tsiprodim, naltrindol, naloksonazin and nor-binaltorphimin that indicate activity opioydnogo receptor as a key component of the effects of Kratom.
Other Kratom effects are reducing smooth muscle tone, local anesthesia, and central nervous system depression. Side effects are as dry mouth, excessive urination, loss of appetite, and constipation. Like morphine, mitragynine reduces secretion stimulated by 2-deoxy-D-glucose acid in the stomach. This could have anorectic effect and manifest in weight loss reported by some Thai. Unlike the opioids in normal doses mitragynine does not cause nausea and vomiting. High doses may cause prolonged sleep, although some people argue that sleep is difficult because of the stimulating effect.
A study was conducted to show that Kratom is effective against malaria. The alkaloid, which is considered the main active ingredient of Kratom, 7-gidroksimitraginin interacts with all three major opioydnymi receptors: delta, kappa and mu, preferring the mu receptor; 7 gidroksimitraginina affinity delta, kappa and mu receptors were 5.6%, 4.6% and 89.8%, respectively. Kratom also contains several Uncaria alkaloids that are found in South American medicinal plant “cat’s claw”. The main substance of the complex is mitrafilin, which exhibits vasodilatory properties and lowers blood pressure. It also relaxes the muscles.